Study Scheduler/USMLE/Step 1
United States Medical Licensing Examination

USMLE Step 1 study schedule.

USMLE Step 1 is the first Step of the physician licensing exam. It has about 280 questions in 14 blocks of 30 minutes, given in one 8-hour day, and it is scored pass/fail. Reproductive and Endocrine Systems (12–16%) and Respiratory and Renal/Urinary Systems (11–15%) are the two largest published shares, and Cardiovascular gets the highest difficulty weighting in Study Scheduler.

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Content

11 topics, each with its share of the exam

Spec version

Effective May 2026

Exam format

8 hours, 9 hours, or two days

Where to put your time first.

Ranked by share of the exam weighted against Study Scheduler's difficulty rating, not share alone, since a smaller topic rated harder can be worth more study time than a bigger, easier one.

1Reproductive and Endocrine Systems12–16%

Pathology · Physiology · Pharmacology · Gross Anatomy & Embryology

2Respiratory and Renal/Urinary Systems11–15%

Pathology · Physiology · Pharmacology · Gross Anatomy & Embryology

3Behavioral Health and Nervous Systems/Special Senses10–14%

Pathology · Physiology · Pharmacology · Gross Anatomy & Embryology

Full Step 1 topic breakdown.

Every topic in the official USMLE content outline, with its share of the exam. Study Scheduler allocates your study hours in this same proportion automatically.

Reproductive and Endocrine Systems12–16%
  • Pathology
  • Physiology
  • Pharmacology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Biochemistry
  • Genetics
Respiratory and Renal/Urinary Systems11–15%
  • Pathology
  • Physiology
  • Pharmacology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Microbiology
  • Biochemistry
Behavioral Health and Nervous Systems/Special Senses10–14%
  • Pathology
  • Physiology
  • Pharmacology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Behavioral Sciences
  • Genetics
Blood & Lymphoreticular/Immune Systems9–13%
  • Pathology
  • Physiology
  • Pharmacology
  • Microbiology
  • Immunology
  • Histology & Cell Biology
  • Genetics
  • Biochemistry
Musculoskeletal, Skin & Subcutaneous Tissue8–12%
  • Pathology
  • Physiology
  • Pharmacology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Microbiology
  • Genetics
Multisystem Processes & Disorders8–12%
  • Pathology
  • Physiology
  • Pharmacology
  • Microbiology
  • Immunology
  • Biochemistry
  • Genetics
  • Nutrition
Cardiovascular System7–11%
  • Pathology
  • Physiology
  • Pharmacology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Biochemistry
  • Genetics
Gastrointestinal System6–10%
  • Pathology
  • Physiology
  • Pharmacology
  • Microbiology
  • Gross Anatomy & Embryology
  • Histology & Cell Biology
  • Biochemistry
  • Nutrition
Communication and Interpersonal Skills6–9%
  • Patient-centered interviewing
  • Breaking bad news
  • Informed consent and shared decision-making
  • Working with families and interpreters
  • Professionalism and ethics
Biostatistics & Epidemiology/Population Health4–6%
  • Study design
  • Measures of disease frequency
  • Sensitivity, specificity and predictive values
  • Hypothesis testing and confidence intervals
  • Bias and confounding
Human Development1–3%
  • Normal growth and development
  • Developmental milestones
  • Aging
  • Sexual development

Frequently asked about Step 1.

What is tested on USMLE Step 1?

The content outline groups questions by organ system, such as Reproductive and Endocrine, Respiratory and Renal/Urinary, Cardiovascular and Gastrointestinal, plus Multisystem Processes and Human Development. Each question also draws on a discipline like pathology, physiology or pharmacology, so the plan rotates through those while you study each system.

Which Step 1 system has the biggest share?

Reproductive and Endocrine Systems, at 12–16% of the exam. Respiratory and Renal/Urinary Systems is next at 11–15%, followed by Behavioral Health and Nervous Systems/Special Senses at 10–14%. The outline classifies each question more than one way, so the percentages overlap.

Is Step 1 scored pass/fail?

Yes. Step 1 reports pass or fail, and your score report marks each content area as lower, the same or higher than a low-pass examinee. Enter those ratings in setup if you are retaking and the plan puts more time into the areas marked lower.

For how many hours to budget, week-by-week study plans, and how Study Scheduler weights your plan — see the full USMLE study guide.

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